Clinical trials of traumatic cervical spine injury treated with internal fixation: Registration project analysis

doi:10.3969/j.issn.2095-4344.2013.22.018

Abstract

Abstract:

BACKGROUND: Traumatic cervical spine injury cannot be ignored, because it will injury the spinal cord and thus leads to paralysis if not treat timely and effectively.
OBJECTIVE: To search the Chinese Clinical Trial Register, North American Clinical Trial Register and Thomson Reuters Web of Science database and to perform literature metrological analysis on the registered projects and published literatures of the relative clinical trials about the traumatic cervical spine injury.
METHODS: The Chinese Clinical Trial Register was searched with the key words of “cervical vertebrae” for the clinical trial program on the traumatic cervical spine injury; the North American Clinical Trial Register was searched with the key words of “cervical vertebra”, “trauma” or “cervical spine”, “Trauma” for the related clinical trials, and a total of 22 registered projects were obtained; the Thomson Reuters Web of Science database was searched with the key words of “neck vertebra, cervical vertebra, vertebrae cervicales, cervical spine, C-Spine, Trauma” for the literatures on the traumatic cervical spine injury published from 2003 to 2012.
RESUTLS AND CONCLUSION: There are only five clinical trial registration projects related to the traumatic cervical spine injury in the Chinese Clinical Trial Register, 22 clinical trial registration projects related to the traumatic cervical spine injury in the North American Clinical Trial Register. The clinical trial registration projects in the Chinese Clinical Trial Register are significantly less than those in the North American Clinical Trial Register. The clinical trial registration projects related to the traumatic cervical spine injury searched from the North American Clinical Trial Register are distributed in three states and 17 countries, and mainly distributed in America. The clinical trial registration projects related to the traumatic cervical spine injury are mainly the intervention studies, and most of the intervention methods are internal fixation. No diagnostic test in the clinical trial registration. The number of literatures on traumatic cervical spine injury published from 2003 to 2012 in the Thomson Reuters Web of Science database have been reached to 1 597, and the amount of literatures published by the United States is accounted for the largest proportion of the total number (46.84%), the Chinese is accounted for 1.94%. The highly cited papers are mainly published on the Journal of Trauma-Injury Infection and Critical Care. The clinical trial registration unit that registered clinical trials on traumatic cervical spine injury in the Chinese Clinical Trial Register did not publish literatures on the Thomson Reuters Web of Science database. The clinical trial registration unit that registered four clinical trials on traumatic cervical spine injury in the North American Clinical Trial Register was the Ottawa Hospital Research Institute, and the unit published the most literatures (30 literatures) was the University of British Columbia, and mainly between 2009 to 2012. The literature on the traumatic cervical spine injury published by the two units above is registered also, the registration number is NCT00290875.

Key words: bone and joint implants, academic discussion of bone and joint, cervical vertebra, trauma, traumatic cervical disease, implant, spine, internal fixation, Chinese Clinical Trial Register, North American Clinical Trial Register, Thomson Reuters Web of Science database, literature bibliometric analysis

CLC Number:

R318

Nan Jun, Yuan Hu, Li Kang-jie. Clinical trials of traumatic cervical spine injury treated with internal fixation: Registration project analysis[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(22): 4115-4122.

Figures/Tables 9

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